InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREB3L3

Summary

InnateDB Protein

IDBP-18338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB3L3

Protein Name

cAMP responsive element binding protein 3-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000078445

InnateDB Gene

IDBG-18336 (CREB3L3)

Protein Structure

UniProt Annotation

Function

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. {ECO:0000250, ECO:0000269PubMed:11353085, ECO:0000269PubMed:15800215, ECO:0000269PubMed:16469704}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:11353085}; Single-pass type II membrane protein {ECO:0000269PubMed:11353085}.Processed cyclic AMP-responsive element- binding protein 3-like protein 3: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Disease Associations

Tissue Specificity

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. {ECO:0000269PubMed:11353085, ECO:0000269PubMed:15800215}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0045944	positive regulation of transcription from RNA polymerase II promoter