Version 5.4
Mus musculus Gene: Cngb1
Summary
InnateDB Gene IDBG-183394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cngb1
Gene Name cyclic nucleotide gated channel beta 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031789
Encoded Proteins
IDBP-400647
cyclic nucleotide gated channel beta 1
IDBP-400645
cyclic nucleotide gated channel beta 1
IDBP-400646
cyclic nucleotide gated channel beta 1
IDBP-789671
cyclic nucleotide gated channel beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070729:
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:95239045-95306585
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000119870 ENSMUSP00000113827
ENSMUST00000120044 ENSMUSP00000113750
ENSMUST00000121162 ENSMUSP00000112437
ENSMUST00000184621
ENSMUST00000184103 ENSMUSP00000139246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005223 intracellular cGMP activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0030553 cGMP binding
GO:0043855 cyclic nucleotide-gated ion channel activity
Biological Process
GO:0007602 phototransduction
GO:0007603 phototransduction, visible light
GO:0007608 sensory perception of smell
GO:0033365 protein localization to organelle
GO:0042391 regulation of membrane potential
GO:0045494 photoreceptor cell maintenance
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070729
View Gene Order
ENSBTAG00000005702
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04740
Olfactory transduction pathway
mmu04744
Phototransduction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163932
Activation of the phototransduction cascade pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_163722
The phototransduction cascade pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_116125
Disease pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa04744
Phototransduction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PXX0 Q80VQ4
UniProt Splice Variant
Entrez Gene 333329
UniGene Mm.484049 Mm.490128
RefSeq NM_001195413 NM_145601 XM_006531140
OMIM
CCDS CCDS52641 CCDS72151
HPRD
IMGT
MGI ID MGI:2664102
MGI Symbol Cngb1
EMBL AC102518 BC046523
GenPept AAH46523
RNA Seq Atlas 333329

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca