InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CNGB1

Summary

InnateDB Gene

IDBG-632701.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNGB1

Gene Name

cyclic nucleotide-gated cation channel beta-1 isoform c

Synonyms

GARP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005702

Encoded Proteins

IDBP-684357

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684374

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684375

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684384

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684386

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684391

cyclic nucleotide-gated cation channel beta-1 isoform c

IDBP-684396

cyclic nucleotide-gated cation channel beta-1 isoform c

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070729:
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:25894541-25963429

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000032434	ENSBTAP00000032366
ENSBTAT00000032433	ENSBTAP00000032365
ENSBTAT00000007490	ENSBTAP00000007490
ENSBTAT00000064084	ENSBTAP00000056058
ENSBTAT00000063004	ENSBTAP00000055137
ENSBTAT00000064172	ENSBTAP00000054194
ENSBTAT00000065243	ENSBTAP00000055261

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030553	cGMP binding

Biological Process

GO:0001895	retina homeostasis
GO:0006812	cation transport
GO:0007603	phototransduction, visible light
GO:0042391	regulation of membrane potential
GO:0050908	detection of light stimulus involved in visual perception
GO:0071805	potassium ion transmembrane transport