InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Edn2

Summary

InnateDB Gene

IDBG-183488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edn2

Gene Name

endothelin 2

Synonyms

VIC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028635

Encoded Proteins

IDBP-183490

endothelin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127129:
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:120161206-120167360

Strand

Forward strand

Band

D2.1

Transcripts

ENSMUST00000030384

ENSMUSP00000030384

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001659	temperature homeostasis
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014824	artery smooth muscle contraction
GO:0014826	vein smooth muscle contraction
GO:0019221	cytokine-mediated signaling pathway
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0030593	neutrophil chemotaxis
GO:0042116	macrophage activation
GO:0042310	vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0048016	inositol phosphate-mediated signaling
GO:0048246	macrophage chemotaxis
GO:0048286	lung alveolus development
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009	energy homeostasis