InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EDN2

Summary

InnateDB Gene

IDBG-97144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDN2

Gene Name

endothelin 2

Synonyms

ET-2; ET2; PPET2

Species

Homo sapiens

Ensembl Gene

ENSG00000127129

Encoded Proteins

IDBP-97146

endothelin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:41478775-41484673

Strand

Reverse strand

Band

p34.2

Transcripts

ENST00000372587	ENSP00000361668
ENST00000490783
ENST00000467046
ENST00000467872
ENST00000460255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001659	temperature homeostasis
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003058	hormonal regulation of the force of heart contraction
GO:0003099	positive regulation of the force of heart contraction by chemical signal
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007166	cell surface receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014824	artery smooth muscle contraction
GO:0014826	vein smooth muscle contraction
GO:0019221	cytokine-mediated signaling pathway
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0030593	neutrophil chemotaxis
GO:0042116	macrophage activation
GO:0042310	vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0048016	inositol phosphate-mediated signaling
GO:0048246	macrophage chemotaxis
GO:0048286	lung alveolus development
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009	energy homeostasis