InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx20

Summary

InnateDB Gene

IDBG-183680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx20

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Synonyms

dp103; GEMIN3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027905

Encoded Proteins

IDBP-183682

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064703:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:105678270-105687574

Strand

Reverse strand

Band

F2.2

Transcripts

ENSMUST00000090680	ENSMUSP00000088176
ENSMUST00000132008

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0019904	protein domain specific binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000387	spliceosomal snRNP assembly
GO:0006200	ATP catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048477	oogenesis
GO:0050810	regulation of steroid biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0017053	transcriptional repressor complex
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex
GO:0097504	Gemini of coiled bodies

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000064703

View Gene Order

ENSBTAG00000018717

Not yet available

Pathways

NETPATH

REACTOME

REACT_224866

Metabolism of non-coding RNA pathway

REACT_206812

snRNP Assembly pathway

REACT_233572

Gene Expression pathway

KEGG

mmu03013

RNA transport pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11066

snRNP Assembly pathway

REACT_11052

Metabolism of non-coding RNA pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

Q9JJY4

TrEMBL

UniProt Splice Variant

Entrez Gene

53975

UniGene

Mm.272826

RefSeq

NM_017397 XM_006501701

OMIM

CCDS

CCDS38581

HPRD

IMGT

MGI ID

MGI:1858415

MGI Symbol

Ddx20

EMBL

AF220454 AJ250027 BC125471 BC137721 CH466608

GenPept

AAF76301 AAI25472 AAI37722 CAB86201 EDL07549

RNA Seq Atlas

53975