InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX20

Summary

InnateDB Gene

IDBG-101097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX20

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Synonyms

DP103; GEMIN3

Species

Homo sapiens

Ensembl Gene

ENSG00000064703

Encoded Proteins

IDBP-101099

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

IDBP-599555

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

IDBP-597887

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111755245-111768016

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000369702	ENSP00000358716
ENST00000475700	ENSP00000435660
ENST00000533164	ENSP00000434085
ENST00000524894
ENST00000534200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000244	spliceosomal tri-snRNP complex assembly
GO:0000387	spliceosomal snRNP assembly
GO:0006200	ATP catabolic process
GO:0006396	RNA processing
GO:0008152	metabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0034660	ncRNA metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048477	oogenesis
GO:0050810	regulation of steroid biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0017053	transcriptional repressor complex
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex
GO:0097504	Gemini of coiled bodies

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027905

View Gene Order

ENSBTAG00000018717

Not yet available

Pathways

NETPATH

REACTOME

REACT_11066

snRNP Assembly pathway

REACT_11052

Metabolism of non-coding RNA pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.591405 Hs.714278

RefSeq

NM_007204

HUGO

OMIM

CCDS

CCDS842

HPRD

05859

IMGT

EMBL

GenPept

RNA Seq Atlas