InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctps

Summary

InnateDB Gene

IDBG-183728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctps

Gene Name

cytidine 5'-triphosphate synthase

Synonyms

Ctps1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028633

Encoded Proteins

IDBP-183730

cytidine 5'-triphosphate synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171793:
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:120539868-120570276

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000030381	ENSMUSP00000030381
ENSMUST00000147980
ENSMUST00000140891

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0044210	'de novo' CTP biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171793

View Gene Order

ENSBTAG00000001626

Not yet available

Pathways

NETPATH

REACTOME

REACT_238368

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_188937

Metabolism pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

mmu00240

Pyrimidine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

P70698

TrEMBL

UniProt Splice Variant

Entrez Gene

51797

UniGene

Mm.1815

RefSeq

NM_016748 XM_006503225

OMIM

CCDS

CCDS18591

HPRD

IMGT

MGI ID

MGI:1858304

MGI Symbol

Ctps

EMBL

AK148259 BC006698 U49350

GenPept

AAB06942 AAH06698 BAE28443

RNA Seq Atlas

51797