InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTPS1

Summary

InnateDB Gene

IDBG-97078.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS1

Gene Name

CTP synthase 1

Synonyms

CTPS; IMD24

Species

Homo sapiens

Ensembl Gene

ENSG00000171793

Encoded Proteins

IDBP-97080

CTP synthase

IDBP-97082

CTP synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:40979335-41012565

Strand

Forward strand

Band

p34.2

Transcripts

ENST00000372621	ENSP00000361704
ENST00000372616	ENSP00000361699
ENST00000470271
ENST00000475060
ENST00000479480
ENST00000480420
ENST00000463285
ENST00000486889
ENST00000497210
ENST00000464283
ENST00000463423
ENST00000498694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0042493	response to drug
GO:0044210	'de novo' CTP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028633

View Gene Order

ENSBTAG00000001626

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.473087

RefSeq

NM_001301237 NM_001905 XM_005270536 XM_006710390 XM_006710391

HUGO

OMIM

CCDS

CCDS459

HPRD

00465

IMGT

EMBL

GenPept

RNA Seq Atlas