InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nedd4

Summary

InnateDB Gene

IDBG-183743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nedd4

Gene Name

neural precursor cell expressed, developmentally down-regulated 4

Synonyms

AA959633; AL023035; AU019897; E430025J12Rik; mKIAA0093; Nedd4-1; Nedd4a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032216

Encoded Proteins

IDBP-183745

neural precursor cell expressed, developmentally down-regulated 4

IDBP-789846

neural precursor cell expressed, developmentally down-regulated 4

IDBP-789847

neural precursor cell expressed, developmentally down-regulated 4

IDBP-789848

neural precursor cell expressed, developmentally down-regulated 4

IDBP-789849

neural precursor cell expressed, developmentally down-regulated 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069869:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:72662346-72749852

Strand

Forward strand

Band

Transcripts

ENSMUST00000034740	ENSMUSP00000034740
ENSMUST00000184737
ENSMUST00000184450	ENSMUSP00000138983
ENSMUST00000183375	ENSMUSP00000138852
ENSMUST00000184386
ENSMUST00000184180
ENSMUST00000184333	ENSMUSP00000139190
ENSMUST00000184020	ENSMUSP00000139297
ENSMUST00000183451
ENSMUST00000184287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 211 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	211 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0019871	sodium channel inhibitor activity
GO:0019904	protein domain specific binding
GO:0031698	beta-2 adrenergic receptor binding
GO:0043130	ubiquitin binding
GO:0050815	phosphoserine binding
GO:0050816	phosphothreonine binding
GO:0070063	RNA polymerase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002250	adaptive immune response
GO:0003151	outflow tract morphogenesis
GO:0003197	endocardial cushion development
GO:0006513	protein monoubiquitination
GO:0006622	protein targeting to lysosome
GO:0007041	lysosomal transport
GO:0007528	neuromuscular junction development
GO:0010766	negative regulation of sodium ion transport
GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567	protein ubiquitination
GO:0019089	transmission of virus
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175	neuron projection development
GO:0031623	receptor internalization
GO:0032801	receptor catabolic process
GO:0034644	cellular response to UV
GO:0034765	regulation of ion transmembrane transport
GO:0042110	T cell activation
GO:0042391	regulation of membrane potential
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111	development involved in symbiotic interaction
GO:0045732	positive regulation of protein catabolic process
GO:0046824	positive regulation of nucleocytoplasmic transport
GO:0048514	blood vessel morphogenesis
GO:0048814	regulation of dendrite morphogenesis
GO:0050807	regulation of synapse organization
GO:0050847	progesterone receptor signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:1901016	regulation of potassium ion transmembrane transporter activity

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm