InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nedd4

Summary

InnateDB Protein

IDBP-789848.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nedd4

Protein Name

neural precursor cell expressed, developmentally down-regulated 4

Synonyms

AA959633; AL023035; AU019897; E430025J12Rik; mKIAA0093; Nedd4-1; Nedd4a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139190

InnateDB Gene

IDBG-183743 (Nedd4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 211 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	211 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019871	sodium channel inhibitor activity
GO:0070064	proline-rich region binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002250	adaptive immune response
GO:0003151	outflow tract morphogenesis
GO:0003197	endocardial cushion development
GO:0006513	protein monoubiquitination
GO:0007528	neuromuscular junction development
GO:0010766	negative regulation of sodium ion transport
GO:0016567	protein ubiquitination
GO:0042110	T cell activation
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0048514	blood vessel morphogenesis
GO:0050807	regulation of synapse organization

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:97297

InterPro

IPR000008 C2 domain
IPR001202 WW domain

PFAM

PF00168
PF00397

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00456

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

V9GXK3

UniProt Splice Variant

Entrez Gene

17999

UniGene

RefSeq

MGI ID

MGI Symbol

Nedd4

OMIM

CCDS

HPRD

IMGT

EMBL

AC123683 CT027588

GenPept