Version 5.4
Mus musculus Gene: Atg4b
Summary
InnateDB Gene IDBG-183781.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg4b
Gene Name autophagy related 4B, cysteine peptidase
Synonyms 2510009N07Rik; Apg4b; Atg4bl; Autl1; AW048066
Species Mus musculus
Ensembl Gene ENSMUSG00000026280
Encoded Proteins
IDBP-183783
autophagy-related 4B (yeast)
IDBP-539010
autophagy-related 4B (yeast)
IDBP-789231
autophagy related 4B, cysteine peptidase
IDBP-789232
autophagy related 4B, cysteine peptidase
IDBP-789238
autophagy related 4B, cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168397:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93751500-93790610
Strand Forward strand
Band D
Transcripts
ENSMUST00000027502 ENSMUSP00000027502
ENSMUST00000149436 ENSMUSP00000123383
ENSMUST00000135762
ENSMUST00000187824 ENSMUSP00000139541
ENSMUST00000185482 ENSMUSP00000140758
ENSMUST00000189152
ENSMUST00000186001
ENSMUST00000189872
ENSMUST00000186811 ENSMUSP00000139463
ENSMUST00000186124
ENSMUST00000185754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168397
View Gene Order
ENSBTAG00000015401
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_174874
OMIM
CCDS CCDS15195
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca