Version 5.4
| Mus musculus Gene: Rap1a | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-183815.6 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | Rap1a | ||||||||||||||||||||||||||||||||||||
| Gene Name | RAS-related protein-1a | ||||||||||||||||||||||||||||||||||||
| Synonyms | AI848598; G-22K; Krev-1; Rap1 | ||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000068798 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
RAS-related protein-1a
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116473:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 3:105727267-105801330 | ||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
| Band | F2.2 | ||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
Hemostasis pathway
Integration of energy metabolism pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Regulation of insulin secretion pathway
Frs2-mediated activation pathway
Rap1 signalling pathway
Signalling to ERKs pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Signalling by NGF pathway
Adaptive Immune System pathway
p130Cas linkage to MAPK signaling for integrins pathway
NGF signalling via TRKA from the plasma membrane pathway
ARMS-mediated activation pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
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| KEGG |
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pancreatic secretion pathway
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| INOH |
Integrin signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
TCR pathway
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| REACTOME |
Rap1 signalling pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Frs2-mediated activation pathway
ARMS-mediated activation pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Signalling by NGF pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Prolonged ERK activation events pathway
Metabolism pathway
Hemostasis pathway
ARMS-mediated activation pathway
Signalling to ERKs pathway
Regulation of insulin secretion pathway
Prolonged ERK activation events pathway
Hemostasis pathway
Immune System pathway
Integration of energy metabolism pathway
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
Signal Transduction pathway
p130Cas linkage to MAPK signaling for integrins pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Integrin alphaIIb beta3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Rap1 signalling pathway
Frs2-mediated activation pathway
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| KEGG |
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pancreatic secretion pathway
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| INOH |
Integrin signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
TCR signaling in naïve CD8+ T cells
Class I PI3K signaling events
Reelin signaling pathway
TCR signaling in naïve CD4+ T cells
EPO signaling pathway
Signaling events regulated by Ret tyrosine kinase
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| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | P62835 | ||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | 109905 | ||||||||||||||||||||||||||||||||||||
| UniGene | Mm.365961 Mm.396701 Mm.458171 | ||||||||||||||||||||||||||||||||||||
| RefSeq | NM_145541 XM_006500907 | ||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | CCDS17711 | ||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:97852 | ||||||||||||||||||||||||||||||||||||
| MGI Symbol | Rap1a | ||||||||||||||||||||||||||||||||||||
| EMBL | BC051419 BC083128 | ||||||||||||||||||||||||||||||||||||
| GenPept | AAH51419 AAH83128 | ||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 109905 | ||||||||||||||||||||||||||||||||||||