InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAP1A

Summary

InnateDB Gene

IDBG-101087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1A

Gene Name

RAP1A, member of RAS oncogene family

Synonyms

C21KG; G-22K; KREV-1; KREV1; RAP1; SMGP21

Species

Homo sapiens

Ensembl Gene

ENSG00000116473

Encoded Proteins

IDBP-101089

RAP1A, member of RAS oncogene family

IDBP-101091

RAP1A, member of RAS oncogene family

IDBP-387703

RAP1A, member of RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111542218-111716691

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000356415	ENSP00000348786
ENST00000369709	ENSP00000358723
ENST00000433097	ENSP00000396741
ENST00000494982

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008565	protein transporter activity
GO:0017016	Ras GTPase binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0032403	protein complex binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0010976	positive regulation of neuron projection development
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0044281	small molecule metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000301	negative regulation of synaptic vesicle exocytosis
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome