Version 5.4
Mus musculus Gene: Nkx6-1
Summary
InnateDB Gene IDBG-183893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkx6-1
Gene Name NK6 homeobox 1
Synonyms Nkx6.1; NKX6A
Species Mus musculus
Ensembl Gene ENSMUSG00000035187
Encoded Proteins
IDBP-183895
NK6 homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163623:
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:101659177-101664996
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000044125 ENSMUSP00000042716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003323 type B pancreatic cell development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007224 smoothened signaling pathway
GO:0008283 cell proliferation
GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021953 central nervous system neuron differentiation
GO:0022008 neurogenesis
GO:0030154 cell differentiation
GO:0030516 regulation of axon extension
GO:0031018 endocrine pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0035094 response to nicotine
GO:0042493 response to drug
GO:0045666 positive regulation of neuron differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0048709 oligodendrocyte differentiation
GO:0071345 cellular response to cytokine stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163623
View Gene Order
ENSBTAG00000002518
Not yet available
Pathways
NETPATH
REACTOME
REACT_208465
Regulation of gene expression in early pancreatic precursor cells pathway
REACT_214529
Regulation of gene expression in beta cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
KEGG
mmu04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_13778
Regulation of gene expression in early pancreatic precursor cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.193072 Mm.405071
RefSeq NM_144955
OMIM
CCDS CCDS19471
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca