Version 5.4
Mus musculus Gene: Akap10
Summary
InnateDB Gene IDBG-183923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap10
Gene Name A kinase (PRKA) anchor protein 10
Synonyms 1500031L16Rik; B130049N18Rik; D-AKAP-2; D-AKAP2; PRKA10
Species Mus musculus
Ensembl Gene ENSMUSG00000047804
Encoded Proteins
IDBP-183925
A kinase (PRKA) anchor protein 10
IDBP-183927
A kinase (PRKA) anchor protein 10
IDBP-263959
A kinase (PRKA) anchor protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21247892
Akap10 is required to induce Ptges2 in the synthesis of NO upon LPS stimulation, in addition Akap10 also mediates the Ptges2-induced expression of cytokines Il10 and Il6 in alveolar macrophages. (Demonstrated in rat models)
InnateDB Annotation from Orthologs
Summary
PMID 21247892
[Homo sapiens] AKAP10 is required to induce PTGES2 in the synthesis of NO upon LPS stimulation, in addition AKAP10 also mediates the PTGES2-induced expression of cytokines IL10 and IL6 in alveolar macrophages. (Demonstrated in rat models)
Entrez Gene
Summary This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61871307-61930252
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000102650 ENSMUSP00000099710
ENSMUST00000058173 ENSMUSP00000054418
ENSMUST00000108710 ENSMUSP00000104350
ENSMUST00000137323
ENSMUST00000143952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051018 protein kinase A binding
Biological Process
GO:0008104 protein localization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108599
View Gene Order
ENSBTAG00000003439
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O88845
TrEMBL
UniProt Splice Variant
Entrez Gene 56697
UniGene Mm.274404 Mm.405315 Mm.474925
RefSeq NM_019921 XM_006533814
OMIM
CCDS CCDS24821
HPRD
IMGT
MGI ID MGI:1890218
MGI Symbol Akap10
EMBL AF021833 AK049399 AL646042 BC054105
GenPept AAC61898 AAH54105 BAC33735 CAI25996 CAI25997 CAI25998
RNA Seq Atlas 56697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca