Version 5.4
Mus musculus Protein: Akap10
Summary
InnateDB Protein IDBP-183927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap10
Protein Name A kinase (PRKA) anchor protein 10
Synonyms 1500031L16Rik; B130049N18Rik; D-AKAP-2; D-AKAP2; PRKA10;
Species Mus musculus
Ensembl Protein ENSMUSP00000054418
InnateDB Gene IDBG-183923 (Akap10)
Protein Structure
UniProt Annotation
Function Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:11248059}. Membrane {ECO:0000269PubMed:11248059}. Cytoplasm {ECO:0000269PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
Disease Associations
Tissue Specificity Highly expressed in testis, kidney and lung, followed by brain, skeletal muscle, liver, spleen and heart. Also expressed in brown adipose tissue and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051018 protein kinase A binding
Biological Process
GO:0008104 protein localization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1890218
InterPro IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PRINTS PR01301
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88845
PhosphoSite PhosphoSite-O88845
TrEMBL
UniProt Splice Variant
Entrez Gene 56697
UniGene Mm.474925
RefSeq
MGI ID
MGI Symbol Akap10
OMIM
CCDS
HPRD
IMGT
EMBL AF021833 AK049399 AL646042 BC054105
GenPept AAC61898 AAH54105 BAC33735 CAI25996 CAI25997 CAI25998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca