InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GUSB

Summary

InnateDB Gene

IDBG-18414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUSB

Gene Name

glucuronidase, beta

Synonyms

BG; MPS7

Species

Homo sapiens

Ensembl Gene

ENSG00000169919

Encoded Proteins

IDBP-18416

glucuronidase, beta

IDBP-376743

glucuronidase, beta

IDBP-376744

glucuronidase, beta

IDBP-376747

glucuronidase, beta

IDBP-376749

glucuronidase, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, Nov 2009]
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:65960684-65982314

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000304895	ENSP00000302728
ENST00000430730	ENSP00000411859
ENST00000447929	ENSP00000411262
ENST00000421103	ENSP00000391390
ENST00000446111	ENSP00000416793
ENST00000466883
ENST00000461622
ENST00000462371
ENST00000465785
ENST00000479038
ENST00000489482
ENST00000475316
ENST00000476486
ENST00000478118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566	beta-glucuronidase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005764	lysosome
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome