Version 5.4
Mus musculus Gene: Chia
Summary
InnateDB Gene IDBG-184306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chia
Gene Name chitinase, acidic
Synonyms 2200003E03Rik; AMCase; Chia; YNL
Species Mus musculus
Ensembl Gene ENSMUSG00000062778
Encoded Proteins
IDBP-184308
chitinase, acidic
IDBP-541557
chitinase, acidic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134216:
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:106113229-106132120
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000079132 ENSMUSP00000078134
ENSMUST00000139086 ENSMUSP00000121967
ENSMUST00000143128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0008061 chitin binding
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0002376 immune system process
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0006030 chitin metabolic process
GO:0006032 chitin catabolic process
GO:0006915 apoptotic process
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134216
View Gene Order
ENSBTAG00000000259
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q91XA9
TrEMBL D3Z1S6
UniProt Splice Variant
Entrez Gene 81600
UniGene Mm.389487
RefSeq NM_023186
OMIM
CCDS CCDS38585
HPRD
IMGT
MGI ID MGI:1932052
MGI Symbol Chia1
EMBL AC125461 AF154571 AF290003 AK008633 AK160173 BC011134 BC034548 CH466608 DQ349202 EF094027
GenPept AAF31644 AAG60018 AAH11134 AAH34548 ABC86699 ABK78778 BAB25795 BAE35672 EDL07527
RNA Seq Atlas 81600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca