Mus musculus Gene: Atf1 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-184326.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Atf1 | ||||||||||||||||||||
Gene Name | activating transcription factor 1 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Gene | ENSMUSG00000023027 | ||||||||||||||||||||
Encoded Proteins |
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123268:
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 15:100227819-100261244 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | F1 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG | |||||||||||||||||||||
INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
NETPATH |
EGFR1 pathway
IL3 pathway
Leptin pathway
IL11 pathway
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REACTOME |
CREB phosphorylation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
CREB phosphorylation pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Signalling by NGF pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Innate Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
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KEGG | |||||||||||||||||||||
INOH | |||||||||||||||||||||
PID NCI |
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | E9PZ49 E9Q356 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 11908 | ||||||||||||||||||||
UniGene | Mm.399842 Mm.473546 Mm.676 | ||||||||||||||||||||
RefSeq | NM_007497 XM_001474817 XM_006520351 XM_006520352 XM_006544560 | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS27832 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
MGI ID | MGI:1298366 | ||||||||||||||||||||
MGI Symbol | Atf1 | ||||||||||||||||||||
EMBL | AC124479 | ||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | 100040260 11908 | ||||||||||||||||||||