InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf1

Summary

InnateDB Protein

IDBP-184328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf1

Protein Name

activating transcription factor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023769

InnateDB Gene

IDBG-184326 (Atf1)

Protein Structure

UniProt Annotation

Function

Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010976	positive regulation of neuron projection development
GO:0014070	response to organic cyclic compound
GO:0032025	response to cobalt ion
GO:0043623	cellular protein complex assembly
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter