Version 5.4
Mus musculus Gene: Arhgap24
Summary
InnateDB Gene IDBG-184391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap24
Gene Name Rho GTPase activating protein 24
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000057315
Encoded Proteins
IDBP-184393
Rho GTPase activating protein 24
IDBP-184395
Rho GTPase activating protein 24
IDBP-184397
Rho GTPase activating protein 24
IDBP-255098
Rho GTPase activating protein 24
IDBP-255100
Rho GTPase activating protein 24
IDBP-255102
Rho GTPase activating protein 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138639:
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:102481391-102897936
Strand Forward strand
Band E5
Transcripts
ENSMUST00000094559 ENSMUSP00000092138
ENSMUST00000073302 ENSMUSP00000073028
ENSMUST00000070000 ENSMUSP00000070048
ENSMUST00000112854 ENSMUSP00000108475
ENSMUST00000112853 ENSMUSP00000108474
ENSMUST00000112852 ENSMUSP00000108473
ENSMUST00000126125
ENSMUST00000130222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0030154 cell differentiation
GO:0032863 activation of Rac GTPase activity
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035313 wound healing, spreading of epidermal cells
GO:1900028 negative regulation of ruffle assembly
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138639
View Gene Order
ENSBTAG00000003959
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8C4V1
TrEMBL D3Z5T4 G3X9N1
UniProt Splice Variant
Entrez Gene 231532
UniGene Mm.400724 Mm.440191
RefSeq NM_001286468 NM_029270 NM_146161 XM_006534887 XM_006534888 XM_006534889 XM_006534890 XM_006534891 XM_006534892
OMIM
CCDS CCDS19474 CCDS19475
HPRD
IMGT
MGI ID MGI:1922647
MGI Symbol Arhgap24
EMBL AC125252 AC139035 AC158944 AK039617 AK080986 BC023344 BC025502 BC027070 CH466529
GenPept AAH23344 AAH25502 AAH27070 BAC30402 BAC38105 EDL20255
RNA Seq Atlas 231532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca