Version 5.4
Mus musculus Protein: Arhgap24
Summary
InnateDB Protein IDBP-255098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap24
Protein Name Rho GTPase activating protein 24
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000108475
InnateDB Gene IDBG-184391 (Arhgap24)
Protein Structure
UniProt Annotation
Function Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell projection {ECO:0000250}. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0030154 cell differentiation
GO:0032863 activation of Rac GTPase activity
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035313 wound healing, spreading of epidermal cells
GO:1900028 negative regulation of ruffle assembly
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0042995 cell projection
Protein Structure and Domains
PDB ID MGI:1922647
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00169
PRINTS
PIRSF
SMART SM00324
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C4V1
PhosphoSite PhosphoSite-Q8C4V1
TrEMBL
UniProt Splice Variant
Entrez Gene 231532
UniGene Mm.440191
RefSeq
MGI ID
MGI Symbol Arhgap24
OMIM
CCDS CCDS19475
HPRD
IMGT
EMBL AK039617 AK080986 BC023344 BC025502 BC027070
GenPept AAH23344 AAH25502 AAH27070 BAC30402 BAC38105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca