Version 5.4
| Mus musculus Gene: Mapk10 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-184558.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Mapk10 | ||||||||||||||||||||||
| Gene Name | mitogen-activated protein kinase 10 | ||||||||||||||||||||||
| Synonyms | C230008H04Rik; JNK3; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); Serk2 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000046709 | ||||||||||||||||||||||
| Encoded Proteins |
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109339:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 5:102907948-103211334 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | E5 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME | |||||||||||||||||||||||
| KEGG |
ErbB signaling pathway pathway
Type II diabetes mellitus pathway
Insulin signaling pathway pathway
Wnt signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Adipocytokine signaling pathway pathway
Focal adhesion pathway
Pancreatic cancer pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Osteoclast differentiation pathway
Protein processing in endoplasmic reticulum pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TSLP pathway
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| REACTOME |
Activation of the AP-1 family of transcription factors pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cellular responses to stress pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
Activated TLR4 signalling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
FCERI mediated MAPK activation pathway
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| KEGG |
GnRH signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Wnt signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
ErbB signaling pathway pathway
MAPK signaling pathway pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Type II diabetes mellitus pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Shigellosis pathway
Toxoplasmosis pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.39253 Mm.439081 Mm.472459 | ||||||||||||||||||||||
| RefSeq | NM_001081567 NM_009158 XM_006534950 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS39185 CCDS51574 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||