InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kdelr1

Summary

InnateDB Gene

IDBG-184648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdelr1

Gene Name

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Synonyms

8030486F04Rik; AW215843; Erd2.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002778

Encoded Proteins

IDBP-184650

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

IDBP-266069

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

IDBP-266071

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105438:
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45872772-45883731

Strand

Forward strand

Band

Transcripts

ENSMUST00000002855	ENSMUSP00000002855
ENSMUST00000107719	ENSMUSP00000103347
ENSMUST00000107718	ENSMUSP00000103346
ENSMUST00000146932
ENSMUST00000133022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0046923	ER retention sequence binding

Biological Process

GO:0006621	protein retention in ER lumen
GO:0008150	biological_process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016021	integral component of membrane
GO:0030663	COPI-coated vesicle membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105438

View Gene Order

ENSBTAG00000004463

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05110

Vibrio cholerae infection pathway

INOH

PID NCI

arf_3pathway

Arf1 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.298433

RefSeq

NM_133950

OMIM

CCDS

CCDS21268

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas