InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdelr1

Summary

InnateDB Protein

IDBP-184650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdelr1

Protein Name

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Synonyms

8030486F04Rik; AW215843; Erd2.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002855

InnateDB Gene

IDBG-184648 (Kdelr1)

Protein Structure

UniProt Annotation

Function

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0046923	ER retention sequence binding

Biological Process

GO:0006621	protein retention in ER lumen
GO:0008150	biological_process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016021	integral component of membrane
GO:0030663	COPI-coated vesicle membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane