InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Figf

Summary

InnateDB Gene

IDBG-184806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Figf

Gene Name

c-fos induced growth factor

Synonyms

AI325264; VEGF-D; Vegfd

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031380

Encoded Proteins

IDBP-184808

c-fos induced growth factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165197:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:164373378-164402650

Strand

Forward strand

Band

Transcripts

ENSMUST00000033751	ENSMUSP00000033751
ENSMUST00000124851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043185	vascular endothelial growth factor receptor 3 binding

Biological Process

GO:0001525	angiogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0060754	positive regulation of mast cell chemotaxis