InnateDB Protein
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IDBP-184808.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Figf
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Protein Name
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c-fos induced growth factor
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Synonyms
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AI325264; VEGF-D; Vegfd;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033751
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InnateDB Gene
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IDBG-184806 (Figf)
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Protein Structure
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Function |
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highly expressed in fetal and adult lung.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:108037
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InterPro |
IPR000072
PDGF/VEGF domain
IPR029034
Cystine-knot cytokine
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PFAM |
PF00341
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PRINTS |
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PIRSF |
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SMART |
SM00141
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TIGRFAMs |
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Modification |
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SwissProt |
P97946
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PhosphoSite |
PhosphoSite-P97946
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14205
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UniGene |
Mm.297978
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RefSeq |
NP_034346
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MGI ID |
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MGI Symbol |
Figf
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OMIM |
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CCDS |
CCDS30521
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HPRD |
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IMGT |
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EMBL |
AL732475
BC080770
D89628
X99572
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GenPept |
AAH80770
BAA14002
CAA67892
CAM17370
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