Version 5.4
| Mus musculus Gene: Ubb | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||
| InnateDB Gene | IDBG-185052.6 | ||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
| Gene Symbol | Ubb | ||||||||||||||||||||
| Gene Name | ubiquitin B | ||||||||||||||||||||
| Synonyms | AL033289; Rps27a; Uba52; Ubb2; Ubc | ||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000019505 | ||||||||||||||||||||
| Encoded Proteins |
ubiquitin B
ubiquitin B
|
||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||
| Summary | Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs. | ||||||||||||||||||||
| Gene Information | |||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||
| Genomic Location | Chromosome 11:62551171-62553213 | ||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||
| Band | B2 | ||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||
| Interactions | |||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||
| Orthologs | |||||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||||
| Pathways | |||||||||||||||||||||
| NETPATH | |||||||||||||||||||||
| REACTOME |
Circadian Clock pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
p53-Independent G1/S DNA damage checkpoint pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Stimuli-sensing channels pathway
Apoptosis pathway
Oxidative Stress Induced Senescence pathway
EGFR downregulation pathway
Downregulation of TGF-beta receptor signaling pathway
G2/M Transition pathway
Mus musculus biological processes pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
G1 Phase pathway
Disease pathway
Synthesis of DNA pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
Signaling by constitutively active EGFR pathway
Circadian Clock pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
DNA Replication pathway
Signaling by WNT in cancer pathway
Membrane Trafficking pathway
Downstream TCR signaling pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Switching of origins to a post-replicative state pathway
Cellular responses to stress pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
degradation of DVL pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by FGFR in disease pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Signaling by ERBB4 pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
FCERI mediated NF-kB activation pathway
Degradation of beta-catenin by the destruction complex pathway
Cytokine Signaling in Immune system pathway
Oncogene Induced Senescence pathway
beta-catenin independent WNT signaling pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Cellular response to hypoxia pathway
p53-Independent DNA Damage Response pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
TGFBR1 LBD Mutants in Cancer pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
Glucose metabolism pathway
regulation of FZD by ubiquitination pathway
TRAF6 mediated induction of TAK1 complex pathway
IRAK2 mediated activation of TAK1 complex pathway
Stabilization of p53 pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Metabolism pathway
Glycogen synthesis pathway
APC/C-mediated degradation of cell cycle proteins pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
TGF-beta receptor signaling activates SMADs pathway
Hedgehog ligand biogenesis pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Downregulation of ERBB4 signaling pathway
ER-Phagosome pathway pathway
Cyclin D associated events in G1 pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Negative regulation of FGFR signaling pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Spry regulation of FGF signaling pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Loss of Function of TGFBR2 in Cancer pathway
Processing-defective Hh variants abrogate ligand secretion pathway
deactivation of the beta-catenin transactivating complex pathway
DNA Repair pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
activated TAK1 mediates p38 MAPK activation pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of DNA replication pathway
Cellular Senescence pathway
Fanconi Anemia pathway pathway
Orc1 removal from chromatin pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
M/G1 Transition pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of Apoptosis pathway
Mitotic G2-G2/M phases pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
Signaling by EGFR pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
p75NTR recruits signalling complexes pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Regulation of mitotic cell cycle pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
APC/C:Cdc20 mediated degradation of Securin pathway
G1/S DNA Damage Checkpoints pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Mitotic Metaphase and Anaphase pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Ion channel transport pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Association of licensing factors with the pre-replicative complex pathway
Fc epsilon receptor (FCERI) signaling pathway
G1/S Transition pathway
Toll-Like Receptors Cascades pathway
Removal of licensing factors from origins pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
APC truncation mutants are not K63 polyubiquitinated pathway
p75NTR signals via NF-kB pathway
Antigen processing-Cross presentation pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
Transmembrane transport of small molecules pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic G1-G1/S phases pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
Glycogen storage diseases pathway
TCF7L2 mutants don't bind CTBP pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Signalling by NGF pathway
Gene Expression pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
truncations of AMER1 destabilize the destruction complex pathway
Loss of Function of TGFBR1 in Cancer pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Regulation of innate immune responses to cytosolic DNA pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signaling by Hedgehog pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Interleukin-1 signaling pathway
Generic Transcription Pathway pathway
MyD88-independent cascade pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
truncated APC mutants destabilize the destruction complex pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
NRIF signals cell death from the nucleus pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Downregulation of ERBB2:ERBB3 signaling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Signaling by NOTCH pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
DNA Replication Pre-Initiation pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
TCR signaling pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Myoclonic epilepsy of Lafora pathway
Mitotic Anaphase pathway
Signaling by EGFR in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Regulation of signaling by CBL pathway
Loss of Function of SMAD2/3 in Cancer pathway
Metabolism of carbohydrates pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Regulation of the Fanconi anemia pathway pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
|
||||||||||||||||||||
| KEGG |
Parkinson's disease pathway
|
||||||||||||||||||||
| INOH | |||||||||||||||||||||
| PID NCI | |||||||||||||||||||||
| Cross-References | |||||||||||||||||||||
| SwissProt | |||||||||||||||||||||
| TrEMBL | A5JUZ1 E9Q5F6 Q5SX22 | ||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||
| Entrez Gene | 22187 | ||||||||||||||||||||
| UniGene | Mm.396503 Mm.455663 | ||||||||||||||||||||
| RefSeq | NM_011664 XM_006533159 | ||||||||||||||||||||
| OMIM | |||||||||||||||||||||
| CCDS | CCDS24826 | ||||||||||||||||||||
| HPRD | |||||||||||||||||||||
| IMGT | |||||||||||||||||||||
| MGI ID | MGI:98888 | ||||||||||||||||||||
| MGI Symbol | Ubb | ||||||||||||||||||||
| EMBL | AC138613 AL596181 EF580991 | ||||||||||||||||||||
| GenPept | ABQ52426 | ||||||||||||||||||||
| RNA Seq Atlas | 22187 | ||||||||||||||||||||