Mus musculus Protein: Ubb | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-185054.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Ubb | ||||||||||||||||||||
Protein Name | ubiquitin B | ||||||||||||||||||||
Synonyms | AL033289; Rps27a; Uba52; Ubb2; Ubc; | ||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Protein | ENSMUSP00000019649 | ||||||||||||||||||||
InnateDB Gene | IDBG-185052 (Ubb) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269PubMed:19754430}. | ||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | MGI:98888 | ||||||||||||||||||||
InterPro |
IPR000626
Ubiquitin-like IPR019956 Ubiquitin IPR022617 Rad60/SUMO-like domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00240
PF14560 PF11976 |
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PRINTS |
PR00348
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PIRSF | |||||||||||||||||||||
SMART |
SM00213
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | P0CG49 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-P0CG49 | ||||||||||||||||||||
TrEMBL | Q78XY9 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 22187 | ||||||||||||||||||||
UniGene | Mm.455663 | ||||||||||||||||||||
RefSeq | NP_035794 | ||||||||||||||||||||
MGI ID | |||||||||||||||||||||
MGI Symbol | Ubb | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS24826 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC138613 AK003190 AK007273 AK010413 AK010625 AK012443 AK013027 AK013873 AK132747 AL596181 BC019850 BC100341 CH466601 EF580991 X51703 | ||||||||||||||||||||
GenPept | AAH19850 AAI00342 ABQ52426 BAB22630 BAB24930 BAB26919 BAB27071 BAB28242 BAB28606 BAB29028 BAE21330 CAA35999 EDL10351 | ||||||||||||||||||||