Version 5.4
Mus musculus Gene: Pabpc4
Summary
InnateDB Gene IDBG-185079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pabpc4
Gene Name poly(A) binding protein, cytoplasmic 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000011257
Encoded Proteins
IDBP-185081
poly(A) binding protein, cytoplasmic 4
IDBP-185083
poly(A) binding protein, cytoplasmic 4
IDBP-269175
poly(A) binding protein, cytoplasmic 4
IDBP-269177
poly(A) binding protein, cytoplasmic 4
IDBP-788629
poly(A) binding protein, cytoplasmic 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090621:
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:123262351-123298925
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000080178 ENSMUSP00000079070
ENSMUST00000078734 ENSMUSP00000077794
ENSMUST00000106243 ENSMUSP00000101850
ENSMUST00000106241 ENSMUSP00000101848
ENSMUST00000156807
ENSMUST00000124991
ENSMUST00000146156
ENSMUST00000183940 ENSMUSP00000139135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0008150 biological_process
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000090621
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu03018
RNA degradation pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.320571
RefSeq NM_130881 NM_148917 XM_006503021 XM_006503022 XM_006503024
OMIM
CCDS CCDS18614 CCDS18615
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca