InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ednrb

Summary

InnateDB Gene

IDBG-185332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ednrb

Gene Name

endothelin receptor type B

Synonyms

ET-B; ET-BR; ETb; ETR-b; Sox10m1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022122

Encoded Proteins

IDBP-185334

endothelin receptor type B

IDBP-620570

endothelin receptor type B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung\'s disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:103814625-103844173

Strand

Reverse strand

Band

E2.3

Transcripts

ENSMUST00000022718	ENSMUSP00000022718
ENSMUST00000172237	ENSMUSP00000126057

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0001934	positive regulation of protein phosphorylation
GO:0006885	regulation of pH
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007422	peripheral nervous system development
GO:0007497	posterior midgut development
GO:0007568	aging
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0014043	negative regulation of neuron maturation
GO:0014070	response to organic cyclic compound
GO:0014826	vein smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0019934	cGMP-mediated signaling
GO:0030318	melanocyte differentiation
GO:0031620	regulation of fever generation
GO:0032269	negative regulation of cellular protein metabolic process
GO:0032496	response to lipopolysaccharide
GO:0035645	enteric smooth muscle cell differentiation
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042045	epithelial fluid transport
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0043066	negative regulation of apoptotic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048246	macrophage chemotaxis
GO:0048265	response to pain
GO:0048484	enteric nervous system development
GO:0050678	regulation of epithelial cell proliferation
GO:0051930	regulation of sensory perception of pain
GO:0060406	positive regulation of penile erection
GO:0071222	cellular response to lipopolysaccharide
GO:0086100	endothelin receptor signaling pathway