InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ednrb

Summary

InnateDB Protein

IDBP-620570.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ednrb

Protein Name

endothelin receptor type B

Synonyms

ET-B; ET-BR; ETb; ETR-b; Sox10m1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126057

InnateDB Gene

IDBG-185332 (Ednrb)

Protein Structure

UniProt Annotation

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0001934	positive regulation of protein phosphorylation
GO:0006885	regulation of pH
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007422	peripheral nervous system development
GO:0007497	posterior midgut development
GO:0007568	aging
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0014043	negative regulation of neuron maturation
GO:0014070	response to organic cyclic compound
GO:0014826	vein smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0019934	cGMP-mediated signaling
GO:0030318	melanocyte differentiation
GO:0031620	regulation of fever generation
GO:0032269	negative regulation of cellular protein metabolic process
GO:0032496	response to lipopolysaccharide
GO:0035645	enteric smooth muscle cell differentiation
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042045	epithelial fluid transport
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0043066	negative regulation of apoptotic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048246	macrophage chemotaxis
GO:0048265	response to pain
GO:0048484	enteric nervous system development
GO:0050678	regulation of epithelial cell proliferation
GO:0051930	regulation of sensory perception of pain
GO:0060406	positive regulation of penile erection
GO:0071222	cellular response to lipopolysaccharide
GO:0086100	endothelin receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:102720

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR001112 Endothelin receptor B
IPR001556 Bombesin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00366
PR00571
PR00358

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48302