InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pou4f1

Summary

InnateDB Gene

IDBG-185464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou4f1

Gene Name

POU domain, class 4, transcription factor 1

Synonyms

Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a; E130119J07Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048349

Encoded Proteins

IDBP-185466

POU domain, class 4, transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152192:
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:104461676-104467999

Strand

Reverse strand

Band

E2.3

Transcripts

ENSMUST00000053016	ENSMUSP00000060798
ENSMUST00000139505

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001967	suckling behavior
GO:0003223	ventricular compact myocardium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007498	mesoderm development
GO:0021535	cell migration in hindbrain
GO:0021559	trigeminal nerve development
GO:0021953	central nervous system neuron differentiation
GO:0021986	habenula development
GO:0030182	neuron differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048665	neuron fate specification
GO:0048880	sensory system development
GO:0048934	peripheral nervous system neuron differentiation
GO:0048935	peripheral nervous system neuron development
GO:0050767	regulation of neurogenesis
GO:0051355	proprioception involved in equilibrioception
GO:0060384	innervation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0043005	neuron projection

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000152192

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.246550 Mm.474944

RefSeq

NM_011143 XM_006518705 XM_006518706

OMIM

CCDS

CCDS27319

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas