InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou4f1

Summary

InnateDB Protein

IDBP-185466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou4f1

Protein Name

POU domain, class 4, transcription factor 1

Synonyms

Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a; E130119J07Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060798

InnateDB Gene

IDBG-185464 (Pou4f1)

Protein Structure

UniProt Annotation

Function

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.0 predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001967	suckling behavior
GO:0003223	ventricular compact myocardium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007498	mesoderm development
GO:0021535	cell migration in hindbrain
GO:0021559	trigeminal nerve development
GO:0021953	central nervous system neuron differentiation
GO:0021986	habenula development
GO:0030182	neuron differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048665	neuron fate specification
GO:0048880	sensory system development
GO:0048934	peripheral nervous system neuron differentiation
GO:0048935	peripheral nervous system neuron development
GO:0050767	regulation of neurogenesis
GO:0051355	proprioception involved in equilibrioception
GO:0060384	innervation