Version 5.4
Mus musculus Gene: Gdf3
Summary
InnateDB Gene IDBG-185634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdf3
Gene Name growth differentiation factor 3
Synonyms C78318; ecat9; Gdf-3; Vgr-2; Vgr2
Species Mus musculus
Ensembl Gene ENSMUSG00000030117
Encoded Proteins
IDBP-185636
growth differentiation factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184344:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122605403-122610087
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000032211 ENSMUSP00000032211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019901 protein kinase binding
Biological Process
GO:0001501 skeletal system development
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0002021 response to dietary excess
GO:0007165 signal transduction
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0010453 regulation of cell fate commitment
GO:0030514 negative regulation of BMP signaling pathway
GO:0030903 notochord development
GO:0032525 somite rostral/caudal axis specification
GO:0040007 growth
GO:0045605 negative regulation of epidermal cell differentiation
GO:0048859 formation of anatomical boundary
GO:0090009 primitive streak formation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000184344
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt Q07104
TrEMBL
UniProt Splice Variant
Entrez Gene 14562
UniGene Mm.299742
RefSeq NM_008108
OMIM
CCDS CCDS20499
HPRD
IMGT
MGI ID MGI:95686
MGI Symbol Gdf3
EMBL AK152457 AK160533 L06443 S52658
GenPept AAA53034 AAB24876 BAE31235 BAE35850
RNA Seq Atlas 14562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca