InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdf3

Summary

InnateDB Protein

IDBP-185636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf3

Protein Name

growth differentiation factor 3

Synonyms

C78318; ecat9; Gdf-3; Vgr-2; Vgr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032211

InnateDB Gene

IDBG-185634 (Gdf3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Primarily in adult bone marrow, spleen, thymus and adipose tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0019901	protein kinase binding

Biological Process

GO:0001501	skeletal system development
GO:0001654	eye development
GO:0001701	in utero embryonic development
GO:0002021	response to dietary excess
GO:0007165	signal transduction
GO:0007492	endoderm development
GO:0007498	mesoderm development
GO:0010453	regulation of cell fate commitment
GO:0030514	negative regulation of BMP signaling pathway
GO:0030903	notochord development
GO:0032525	somite rostral/caudal axis specification
GO:0040007	growth
GO:0045605	negative regulation of epidermal cell differentiation
GO:0048859	formation of anatomical boundary
GO:0090009	primitive streak formation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:95686

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt