InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps4b

Summary

InnateDB Gene

IDBG-185780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps4b

Gene Name

vacuolar protein sorting 4b (yeast)

Synonyms

8030489C12Rik; Skd1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009907

Encoded Proteins

IDBP-185782

vacuolar protein sorting 4b (yeast)

IDBP-255377

vacuolar protein sorting 4b (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119541:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:106764071-106796728

Strand

Reverse strand

Band

E2.1

Transcripts

ENSMUST00000094646	ENSMUSP00000092230
ENSMUST00000112736	ENSMUSP00000108356
ENSMUST00000147705
ENSMUST00000127606
ENSMUST00000126057
ENSMUST00000190531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006813	potassium ion transport
GO:0007032	endosome organization
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0030301	cholesterol transport
GO:0032367	intracellular cholesterol transport
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
GO:0033993	response to lipid
GO:0050792	regulation of viral process
GO:0051301	cell division
GO:1902188	positive regulation of viral release from host cell

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005774	vacuolar membrane
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome