InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VPS4B

Summary

InnateDB Gene

IDBG-4397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS4B

Gene Name

vacuolar protein sorting 4 homolog B (S. cerevisiae)

Synonyms

SKD1; SKD1B; VPS4-2

Species

Homo sapiens

Ensembl Gene

ENSG00000119541

Encoded Proteins

IDBP-4399

vacuolar protein sorting 4 homolog B (S. cerevisiae)

IDBP-726649

IDBP-725839

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:63389190-63422483

Strand

Reverse strand

Band

q21.33

Transcripts

ENST00000238497	ENSP00000238497
ENST00000588323
ENST00000588059	ENSP00000465944
ENST00000591519	ENSP00000465846
ENST00000591475
ENST00000591383
ENST00000589604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0042623	ATPase activity, coupled

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006813	potassium ion transport
GO:0007032	endosome organization
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0030301	cholesterol transport
GO:0032367	intracellular cholesterol transport
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
GO:0033993	response to lipid
GO:0050792	regulation of viral process
GO:0051301	cell division
GO:0061024	membrane organization
GO:1902188	positive regulation of viral release from host cell

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005774	vacuolar membrane
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009907

View Gene Order

ENSBTAG00000010492

Not yet available

Pathways

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.126550

RefSeq

NM_004869

HUGO

OMIM

CCDS

CCDS11983

HPRD

15653

IMGT

EMBL

GenPept

RNA Seq Atlas