Version 5.4
Mus musculus Gene: Kcnc1
Summary
InnateDB Gene IDBG-186082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnc1
Gene Name potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms C230009H10Rik; Kcr2-1; KShIIIB; Kv3.1; KV4; NGK2; Shaw
Species Mus musculus
Ensembl Gene ENSMUSG00000058975
Encoded Proteins
IDBP-186086
potassium voltage gated channel, Shaw-related subfamily, member 1
IDBP-542558
potassium voltage gated channel, Shaw-related subfamily, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129159:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Multiple transcript variants encoding different isoforms have been inferred for this gene based on orthologous loci. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46396497-46438375
Strand Forward strand
Band B3
Transcripts
ENSMUST00000025202 ENSMUSP00000025202
ENSMUST00000160433 ENSMUSP00000124938
ENSMUST00000160234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0019894 kinesin binding
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030673 axolemma
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129159
View Gene Order
ENSBTAG00000005424
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P15388
TrEMBL E9PVV3 Q3TR92 Q3UHB6
UniProt Splice Variant
Entrez Gene 16502
UniGene Mm.249386 Mm.466281
RefSeq NM_001112739 NM_008421 XM_006540647
OMIM
CCDS CCDS21278 CCDS52252
HPRD
IMGT
MGI ID MGI:96667
MGI Symbol Kcnc1
EMBL AC020786 AC090652 AK147476 AK147682 AK162964 BC125470 BC132439 CH466603 Y07521
GenPept AAI25471 AAI32440 BAE27941 BAE28071 BAE37138 CAA68814 EDL22928
RNA Seq Atlas 16502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca