InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNC1

Summary

InnateDB Gene

IDBG-34306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNC1

Gene Name

potassium voltage-gated channel, Shaw-related subfamily, member 1

Synonyms

KV3.1; KV4; NGK2

Species

Homo sapiens

Ensembl Gene

ENSG00000129159

Encoded Proteins

IDBP-34308

potassium voltage-gated channel, Shaw-related subfamily, member 1

IDBP-34359

potassium voltage-gated channel, Shaw-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Multiple transcript variants encoding different isoforms have been inferred for this gene based on orthologous loci. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:17734812-17783055

Strand

Forward strand

Band

p15.1

Transcripts

ENST00000265969	ENSP00000265969
ENST00000379472	ENSP00000368785
ENST00000525802
ENST00000526029

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030673	axolemma
GO:0032590	dendrite membrane
GO:0032809	neuronal cell body membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000058975

View Gene Order

ENSBTAG00000005424

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.552896

RefSeq

NM_001112741 NM_004976

HUGO

OMIM

CCDS

CCDS44547 CCDS7827

HPRD

15936

IMGT

EMBL

GenPept

RNA Seq Atlas