Version 5.4
Mus musculus Gene: Abcc4
Summary
InnateDB Gene IDBG-186342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcc4
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032849
Encoded Proteins
IDBP-186344
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
IDBP-620580
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125257:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:118482692-118706219
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000036554 ENSMUSP00000042186
ENSMUST00000166646 ENSMUSP00000129677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0015238 drug transmembrane transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006855 drug transmembrane transport
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0042493 response to drug
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031088 platelet dense granule membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125257
View Gene Order
ENSBTAG00000032603
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu02010
ABC transporters pathway
mmu04976
Bile secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa02010
ABC transporters pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q236 E9Q467
UniProt Splice Variant
Entrez Gene 239273
UniGene Mm.40537
RefSeq NM_001033336 NM_001163675 NM_001163676
OMIM
CCDS CCDS27335 CCDS49565
HPRD
IMGT
MGI ID MGI:2443111
MGI Symbol Abcc4
EMBL AC154419 AC167668 CT025694
GenPept
RNA Seq Atlas 239273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca