Version 5.4
Homo sapiens Gene: AP2A2
Summary
InnateDB Gene IDBG-18640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP2A2
Gene Name adaptor-related protein complex 2, alpha 2 subunit
Synonyms ADTAB; CLAPA2; HIP-9; HIP9; HYPJ
Species Homo sapiens
Ensembl Gene ENSG00000183020
Encoded Proteins
IDBP-18642
adaptor-related protein complex 2, alpha 2 subunit
IDBP-360988
adaptor-related protein complex 2, alpha 2 subunit
IDBP-592887
adaptor-related protein complex 2, alpha 2 subunit
IDBP-603178
adaptor-related protein complex 2, alpha 2 subunit
IDBP-596058
adaptor-related protein complex 2, alpha 2 subunit
IDBP-593140
adaptor-related protein complex 2, alpha 2 subunit
IDBP-585333
adaptor-related protein complex 2, alpha 2 subunit
IDBP-595640
adaptor-related protein complex 2, alpha 2 subunit
IDBP-583834
adaptor-related protein complex 2, alpha 2 subunit
IDBP-602184
adaptor-related protein complex 2, alpha 2 subunit
IDBP-585946
adaptor-related protein complex 2, alpha 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:924894-1012245
Strand Forward strand
Band p15.5
Transcripts
ENST00000332231 ENSP00000327694
ENST00000448903 ENSP00000413234
ENST00000529818
ENST00000529858
ENST00000525796 ENSP00000437228
ENST00000534328 ENSP00000436059
ENST00000528815 ENSP00000431630
ENST00000528195
ENST00000531548 ENSP00000433498
ENST00000534485 ENSP00000435756
ENST00000527024 ENSP00000434563
ENST00000526753 ENSP00000435863
ENST00000530801 ENSP00000434553
ENST00000524559 ENSP00000434432
ENST00000527917
ENST00000524952
ENST00000525891
ENST00000529438
ENST00000526401
ENST00000526376
ENST00000529427
ENST00000531497
ENST00000528816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0008565 protein transporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002957
View Gene Order
ENSBTAG00000009915
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.19121 Hs.603194 Hs.735467
RefSeq NM_001242837 NM_012305 XM_006718159 XM_006718160
HUGO
OMIM
CCDS CCDS44512 CCDS73234
HPRD 06256
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca