Version 5.4
Mus musculus Gene: Ap2a2
Summary
InnateDB Gene IDBG-212321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap2a2
Gene Name adaptor protein complex AP-2, alpha 2 subunit
Synonyms 2410074K14Rik; Adtab; AF006990; AW146353; C78001; L25
Species Mus musculus
Ensembl Gene ENSMUSG00000002957
Encoded Proteins
IDBP-212323
adaptor protein complex AP-2, alpha 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183020:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141562180-141633011
Strand Forward strand
Band F5
Transcripts
ENSMUST00000003038 ENSMUSP00000003038
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183020
View Gene Order
ENSBTAG00000009915
Not yet available
Pathways
NETPATH
REACTOME
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_232605
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_230745
Immune System pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_214043
PCP/CE pathway pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_242976
Signaling by EGFR pathway
REACT_261444
Axon guidance pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_253367
Trafficking of GluR2-containing AMPA receptors pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_244428
Trafficking of AMPA receptors pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu05016
Huntington's disease pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_212636
Signaling by Wnt pathway
REACT_208036
Signaling by EGFR pathway
REACT_223433
Recycling pathway of L1 pathway
REACT_217496
Trafficking of GluR2-containing AMPA receptors pathway
REACT_202205
Retrograde neurotrophin signalling pathway
REACT_217562
WNT5A-dependent internalization of FZD4 pathway
REACT_215526
L1CAM interactions pathway
REACT_213138
Immune System pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_203140
Axon guidance pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_207926
PCP/CE pathway pathway
REACT_225032
Neuronal System pathway
REACT_219681
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_207066
Signalling by NGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_217186
EGFR downregulation pathway
REACT_214196
Trafficking of AMPA receptors pathway
REACT_207087
Disease pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt P17427
TrEMBL Q69ZW4
UniProt Splice Variant
Entrez Gene 11772
UniGene Mm.253090 Mm.473945 Mm.474100
RefSeq NM_007459 XM_006536154
OMIM
CCDS CCDS40188
HPRD
IMGT
MGI ID MGI:101920
MGI Symbol Ap2a2
EMBL AC102524 AC158224 AF006990 AK088500 AK173054 BC010597 X14972
GenPept AAB62703 AAH10597 BAC40392 BAD32332 CAA33097
RNA Seq Atlas 11772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca