Version 5.4
Mus musculus Gene: Fhl3
Summary
InnateDB Gene IDBG-186622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fhl3
Gene Name four and a half LIM domains 3
Synonyms SLIM2
Species Mus musculus
Ensembl Gene ENSMUSG00000032643
Encoded Proteins
IDBP-186624
four and a half LIM domains 3
IDBP-269267
four and a half LIM domains 3
IDBP-539871
four and a half LIM domains 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183386:
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:124700701-124708611
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000038684 ENSMUSP00000040150
ENSMUST00000106199 ENSMUSP00000101805
ENSMUST00000145942 ENSMUSP00000121702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183386
View Gene Order
ENSBTAG00000007300
Not yet available
Cross-References
SwissProt Q9R059
TrEMBL
UniProt Splice Variant
Entrez Gene 14201
UniGene Mm.331856
RefSeq NM_010213 XM_006502766 XM_006502768
OMIM
CCDS CCDS38874
HPRD
IMGT
MGI ID MGI:1341092
MGI Symbol Fhl3
EMBL AF114382 AF134772 AF149826 AL606907 BC144903 BC145939
GenPept AAD32623 AAD53231 AAF73159 AAI44904 AAI45940
RNA Seq Atlas 14201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca