InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HRH1

Summary

InnateDB Gene

IDBG-18663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRH1

Gene Name

histamine receptor H1

Synonyms

H1-R; hisH1

Species

Homo sapiens

Ensembl Gene

ENSG00000196639

Encoded Proteins

IDBP-236211

histamine receptor H1

IDBP-363287

histamine receptor H1

IDBP-363289

histamine receptor H1

IDBP-363291

histamine receptor H1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:11137093-11263557

Strand

Forward strand

Band

p25.3

Transcripts

ENST00000397056	ENSP00000380247
ENST00000438284	ENSP00000406705
ENST00000431010	ENSP00000397028
ENST00000413416	ENSP00000392383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007613	memory
GO:0008542	visual learning
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0043114	regulation of vascular permeability
GO:0045907	positive regulation of vasoconstriction
GO:0048016	inositol phosphate-mediated signaling
GO:0048167	regulation of synaptic plasticity
GO:0048245	eosinophil chemotaxis
GO:0071420	cellular response to histamine

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053004

View Gene Order

ENSBTAG00000001447

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_16903

Histamine receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P35367

TrEMBL

UniProt Splice Variant

Entrez Gene

3269

UniGene

Hs.1570

RefSeq

NM_000861 NM_001098211 NM_001098212 NM_001098213

HUGO

HGNC:5182

OMIM

600167

CCDS

CCDS2604

HPRD

02544

IMGT

EMBL

AB041380 AF026261 AK289412 AY136743 BC060802 CH471055 D14436 D28481 X76786 Z34897

GenPept

AAB95156 AAH60802 AAN01269 BAA03319 BAA05840 BAA94465 BAF82101 CAA54182 CAA84380 EAW64092

RNA Seq Atlas

3269