InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hrh1

Summary

InnateDB Gene

IDBG-178946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hrh1

Gene Name

histamine receptor H1

Synonyms

Bphs; H1R; HH1R; Hir

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053004

Encoded Proteins

IDBP-178948

histamine receptor H1

IDBP-532745

histamine receptor H1

IDBP-535032

histamine receptor H1

IDBP-535351

histamine receptor H1

IDBP-539392

histamine receptor H1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196639:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:114397936-114483296

Strand

Forward strand

Band

Transcripts

ENSMUST00000088987	ENSMUSP00000086383
ENSMUST00000160212	ENSMUSP00000125316
ENSMUST00000161650	ENSMUSP00000124460
ENSMUST00000161220	ENSMUSP00000124037
ENSMUST00000160780	ENSMUSP00000124320

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0015085	calcium ion transmembrane transporter activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007613	memory
GO:0008542	visual learning
GO:0043114	regulation of vascular permeability
GO:0045907	positive regulation of vasoconstriction
GO:0048167	regulation of synaptic plasticity
GO:0048245	eosinophil chemotaxis
GO:0048511	rhythmic process
GO:0070509	calcium ion import
GO:0071420	cellular response to histamine
GO:0071421	manganese ion transmembrane transport