Version 5.4
Mus musculus Gene: Tgfbr3
Summary
InnateDB Gene IDBG-186670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgfbr3
Gene Name transforming growth factor, beta receptor III
Synonyms 1110036H20Rik; AU015626; AW215636; TBRIII
Species Mus musculus
Ensembl Gene ENSMUSG00000029287
Encoded Proteins
IDBP-186672
transforming growth factor, beta receptor III
IDBP-537083
transforming growth factor, beta receptor III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069702:
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:107106570-107289629
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000031224 ENSMUSP00000031224
ENSMUST00000138469
ENSMUST00000136882 ENSMUSP00000123644
ENSMUST00000146591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0015026 coreceptor activity
GO:0017134 fibroblast growth factor binding
GO:0030165 PDZ domain binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
GO:0070123 transforming growth factor beta receptor activity, type III
Biological Process
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0003347 epicardial cell to mesenchymal cell transition
GO:0006461 protein complex assembly
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007181 transforming growth factor beta receptor complex assembly
GO:0009790 embryo development
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016049 cell growth
GO:0030509 BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 organ regeneration
GO:0032354 response to follicle-stimulating hormone
GO:0034695 response to prostaglandin E
GO:0034699 response to luteinizing hormone stimulus
GO:0035556 intracellular signal transduction
GO:0043393 regulation of protein binding
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050880 regulation of blood vessel size
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051271 negative regulation of cellular component movement
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060021 palate development
GO:0060038 cardiac muscle cell proliferation
GO:0060216 definitive hemopoiesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060318 definitive erythrocyte differentiation
GO:0060347 heart trabecula formation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060976 coronary vasculature development
GO:0060977 coronary vasculature morphogenesis
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0061032 visceral serous pericardium development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069702
View Gene Order
ENSBTAG00000024269
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt O88393
TrEMBL
UniProt Splice Variant
Entrez Gene 21814
UniGene Mm.200775 Mm.407067
RefSeq NM_011578
OMIM
CCDS CCDS19499
HPRD
IMGT
MGI ID MGI:104637
MGI Symbol Tgfbr3
EMBL AF039601 BC070428
GenPept AAC28564 AAH70428
RNA Seq Atlas 21814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca