Version 5.4
Bos taurus Gene: TGFBR3
Summary
InnateDB Gene IDBG-636658.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFBR3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000024269
Encoded Proteins
IDBP-688635
transforming growth factor, beta receptor III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069702:
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:51661004-51866717
Strand Forward strand
Band
Transcripts
ENSBTAT00000033522 ENSBTAP00000033435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0015026 coreceptor activity
GO:0030165 PDZ domain binding
GO:0046332 SMAD binding
GO:0050431 transforming growth factor beta binding
GO:0070123 transforming growth factor beta receptor activity, type III
Biological Process
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0030509 BMP signaling pathway
GO:0032354 response to follicle-stimulating hormone
GO:0034695 response to prostaglandin E
GO:0034699 response to luteinizing hormone stimulus
GO:0035556 intracellular signal transduction
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051271 negative regulation of cellular component movement
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060021 palate development
GO:0060038 cardiac muscle cell proliferation
GO:0060216 definitive hemopoiesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060318 definitive erythrocyte differentiation
GO:0060347 heart trabecula formation
GO:0060389 pathway-restricted SMAD protein phosphorylation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000069702
View Gene Order
ENSMUSG00000029287
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL E1B9H5
UniProt Splice Variant
Entrez Gene 784894
UniGene Bt.64570
RefSeq XM_005197828 XM_005197829 XM_005197830 XM_005197831 XM_005204335 XM_005204336 XM_005204337 XM_005204338
HUGO HGNC:11774
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007909 DAAA02007910 DAAA02007911
GenPept
RNA Seq Atlas 784894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca