Version 5.4
Mus musculus Gene: Ces4a
Summary
InnateDB Gene IDBG-186729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ces4a
Gene Name carboxylesterase 4A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000060560
Encoded Proteins
IDBP-540030
carboxylesterase 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172824:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105131800-105150109
Strand Forward strand
Band D3
Transcripts
ENSMUST00000161289 ENSMUSP00000125062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172824
View Gene Order
ENSBTAG00000038325
Not yet available
Cross-References
SwissProt Q8R0W5
TrEMBL
UniProt Splice Variant
Entrez Gene 234677
UniGene Mm.120297
RefSeq NM_146213
OMIM
CCDS CCDS22591
HPRD
IMGT
MGI ID MGI:2384581
MGI Symbol Ces4a
EMBL AC164311 BC026374 CH466525
GenPept AAH26374 EDL11247
RNA Seq Atlas 234677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca